Endocrine Abstracts

Thyroid hormones (TH)s have as a major target the heart, where they regulate many different functions, including the modulation of the heart rate and myocyte contractility. Their effects on ventricular repolarization are controversial and QT prolongation was reported both in patients with hypothyroidism and hyperthyroidism, in their overt or subclinical forms. We analyzed the effects of 3.3',5.5'-tetraiodo-L-Thyronine (T4), 3.3',5-triiodo-L-Thyronine (T3) and of 3.3',5'-triiod...

In COVID-19 patients the occurrence of low T3 serum values is associated with disease severity and death, but hormonal substitutive replacement is still debated. Clinical trials reported so far failed to demonstrate clear beneficial effects of T3, T4 or both treatments. With the aim to analyze the peripheral effects of the acute deficiency of T3 in blood, we analyzed body fluid composition in 74 COVID-19 patients, admitted to our University Hospital during the last pandemic wa...

We have previously shown that Low T3 syndrome is associated with serum markers, radiologic and clinical scores of COVID-19 severity and it can be considered as a novel biomarker of the severity of the disease (Endocrine Abstracts 2020, 70 AEP1091). With the aim to analyze the mechanisms that are at the basis of this condition as well as the pathways involved, we applied an integrative approach of multi-omics data. We performed: i) multiplex cytokine assay, using the B...

Low T3 syndrome is a frequent finding in patients with critical illness, particularly in those admitted to intensive care units. It is generally considered an adaptive state of thyroid hormone (TH) economy, but many evidences indicate that it may represent a negative prognostic factor too. The prevalence and clinical relevance of the Low T3 syndrome in coronavirus infections has not been evaluated yet. We have measured thyroid hormone levels and analyzed anamnestic, epidemiolo...